| Date | Players | Pos | Injury | Status | Comment |
|---|---|---|---|---|---|
| 08/31/09 | Travis Schlichting | RP | Back injury | On 60-day DL | Expected return 04/04/10 |
| 08/06/09 | Jason Schmidt | SP | Right shoulder soreness | On 60-day DL | Expected return 04/01/10 |
| 06/28/09 | Eric Milton | SP | Lower back surgery - out for season | Off 60-day DL | Expected return 03/30/10 |
| 05/21/09 | Xavier Paul | RF | Skin infection, left leg | On 60-day DL | Expected return 04/05/10 |
| Date | Players | Pos | Transaction |
|---|---|---|---|
| 11/11 | Jason Schmidt | P | Declared Free Agency |
| 11/09 | Will Ohman | P | Removed From 60-Day DL |
| 11/09 | Will Ohman | P | Declared Free Agency |
| 11/09 | Juan Castro | SS | Declared Free Agency |
| 11/09 | Mark Loretta | 3B | Declared Free Agency |
| 11/09 | Jason Schmidt | P | Removed From 60-Day DL |
| 11/09 | Travis Schlichting | P | Removed From 60-Day DL |
| 11/09 | Xavier Paul | RF | Removed From 60-Day DL |
| 11/06 | Brad Ausmus | C | Declared Free Agency |
| 11/06 | Guillermo Mota | P | Declared Free Agency |
| 11/06 | Vicente Padilla | P | Declared Free Agency |
| 11/06 | Jim Thome | 1B | Declared Free Agency |
| 11/06 | Jeff Weaver | P | Declared Free Agency |
| 11/06 | Manny Ramirez | LF | Signed |
| 11/05 | Ronnie Belliard | 2B | Declared Free Agency |
| 11/05 | Orlando Hudson | 2B | Declared Free Agency |
| 11/05 | Doug Mientkiewicz | 1B | Declared Free Agency |
| 11/05 | Eric Milton | P | Removed From 60-Day DL |
| 11/05 | Eric Milton | P | Declared Free Agency |
| 11/05 | Randy Wolf | P | Declared Free Agency |
| 11/05 | Jon Garland | P | Declared Free Agency |